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Title

Advances in Protein Chemistry and Structural Biology : Fidelity and Quality Control in Gene Expression.

Author
Series
  • (CKB)1000000000701787
Other titles
  • Advances in Protein Chemistry and Structural Biology, Volume 86
Published
  • Burlington : Elsevier Science 2012
Physical description
1 online resource (267 p.)
ISBN
  • 1283434121
  • 9786613434128
  • 0123864984
  • 0123864976
Notes
  • Description based upon print version of record.
  • English
Contents
  • Front Cover; Fidelity and Quality Control in Gene Expression; Copyright; Contents; Preface; Chapter 1: Quality control in aminoacyl-tRNA synthesis: Its Role in Translational Fidelity; I. Introduction; A. Aminoacyl-tRNA Synthesis; B. Substrate Selection by aaRS; C. History of aaRS Editing; D. aaRS Editing Pathways; II. Class I aaRS Editing Mechanisms; A. CP1-Dependent Editing by IleRS, LeuRS, and ValRS; B. Mechanisms and Partitioning of Pre- Versus Posttransfer Editing; C. Editing via Intramolecular Cyclization by MetRS; III. Class II aaRS Editing Mechanisms; A. ThrRS; B. PheRS; C. AlaRS
  • D. ProRSE. SerRS; F. LysRS-II; IV. Nucleotide Determinants for Editing; V. Trans-Editing Factors and Triple Sieves; VI. Loss of Editing Function in aaRS; VII. Mistranslation and Role of Editing in Cell; Acknowledgments; References; Chapter 2: Termination and post-termination events in eukaryotic translation; I. Introduction; II. Termination; III. Ribosome Recycling; IV. Reinitiation; A. Reinitiation After Translation of a Short uORF; B. Differences Between Post-uORF Reinitiation in Yeast and Mammalian Cells; C. The Dependence of Post-uORF Reinitiation on eIF2-TC Availability
  • D. Sequence-Specific Inhibitory uORFs in Mammalian mRNAsE. Reinitiation After a Long ORF: The Calicivirus Paradigm; F. Other Cases of Reinitiation After a Long ORF; G. A Bizarre Termination-Reinitiation Event in the Translation of Cardio- and Aphthovirus Genomes; Acknowledgments; References; Chapter 3: Quality control of mRNA decoding on the bacterial ribosome; I. Introduction; II. Speed and Fidelity of Translation in vivo; A. In vivo Numbers; B. The Fidelity Problem; III. Substrate Selection During Translation Initiation; A. Mechanism of Initiation; B. Selection of mRNA
  • C. Selection of Initiator tRNA and Start CodonIV. Fidelity of Elongation; A. Mechanism of Decoding During Elongation; B. Kinetic Principles of Substrate Selection; C. Structural Basis of Codon-Anticodon Recognition by the Ribosome; D. The Role of the tRNA; E. Uniformity of Decoding; F. Trade-Off Between Speed and Accuracy; G. Retrospective Editing; V. Termination Fidelity; A. Mechanism of Termination; B. Recognition of Termination Codons by RF1 and RF2; C. Fidelity of Peptide Release; VI. Conclusions; Acknowledgments; References; Chapter 4: Control of gene expression by translational recoding
  • I. IntroductionII. Programmed -1 Ribosomal Frameshifting; A. Introduction and History; B. PRF in Viruses: The ``Golden Mean ́ ́ and Possible Therapeutic Applications; C. Computational Identification of -1 PRF Signals: Genomic Frameshifting; D. -1 PRF in Cellular mRNAs: mRNA Destabilization Elements and Regulation of Gene Expression; III. Programmed +1 Ribosomal Frameshifting; A. History of +1 PRF: Retrotransposable Elements; B. Cellular +1 PRF; 1. Ornithine Decarboxylase Antizyme; 2. Other Examples of Cellular +1 Frameshifting; IV. Selenocysteine and Pyrrolysine: The 21st and 22nd Amino Acids
  • A. Selenocysteine
Summary
  • The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting. Provides a comprehensi
  • The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.
Subject
Other names
Genre
  • Electronic books.
  • text
Language
  • English
Internet Resources
Direct Link
https://copac.jisc.ac.uk/id/10257962?style=html&title=Advances%20in%20Protein%20Chemistry%20and%20Structural%20BiologyFidelity
Format
  • Online

Held At

  1. Manchester University Online Information about Manchester University

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