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Title

Advances in Protein Chemistry and Structural Biology : Inflammation in Neuropsychiatric Disorders.

Author
Series
  • (CKB)1000000000701787
Other titles
  • Advances in Protein Chemistry and Structural Biology, Volume 88
  • Inflammation in Neuropsychiatric Disorders
Published
  • Burlington : Elsevier Science 2012
Physical description
1 online resource (201 p.)
ISBN
  • 128213423X
  • 9786613806819
  • 0123983207
  • 0123983142
Notes
  • Description based upon print version of record.
  • English
Contents
  • Front Cover; Advances in Protein Chemistry and Structural Biology; Copyright; Contents; Preface; Chapter 1: Inflammation in Anxiety; 1. Introduction; 2. Cytokines, Brain, and Behavior; 3. Inflammation in Anxiety Disorders; 4. Inflammation in Anxiety Disorders: Potential Role of Oxidative Stress; 5. Oxidative Stress, Transcription Factors, and Inflammation; 6. Conclusion; Acknowledgments; References; Chapter 2: Inflammation-Related Disorders in the Tryptophan Catabolite Pathway in Depression and Somatization; 1. Introduction; 2. Tryptophan and the TRYCAT Pathway
  • 3. The TRYCAT Pathway in Somatization4. Activation of the TRYCAT Pathway May Cause Somatization; 5. The TRYCAT Pathway, the CNS, and Somatization; 6. Summary; 7. Potential Treatment Implications; References; Chapter 3: Inflammation in Schizophrenia; 1. Introduction; 2. The Immune Response and the Type-1 and Type-2 Polarization; 3. Inflammation in Schizophrenia; 4. Type-1 and Type-2 Immune Response in Schizophrenia; 5. Antipsychotic Drugs and the Type-1/Type-2 Imbalance in Schizophrenia; 6. The Monocyte/Macrophage System in Schizophrenia
  • 7. Brain Imaging and Microglia Activation in Schizophrenia8. The Tryptophan-Kynurenine Metabolism in Schizophrenia; 9. Treatment Options for Schizophrenia Based on Immune Modulation; 10. COX-2 Inhibition as Therapeutic Approach in Schizophrenia; Acknowledgment; References; Chapter 4: Inflammation in Parkinsons Disease; 1. Introduction; 2. Parkinsons Disease; 2.1. Epidemiology; 2.2. Risk and protective factors; 2.3. Clinical findings; 2.4. Treatment; 3. Inflammation in PD; 3.1. Inflammation in neurodegenerative diseases; 3.2. Hallmarks of inflammation; 3.2.1. Microglia; 3.2.2. Astrocytes
  • 3.2.3. Adaptive immune system3.2.4. Soluble protein mediators; 4. Evidence of Inflammation in PD; 4.1. Postmortem studies; 4.2. Imaging studies; 4.3. Analysis of CSF samples; 4.4. Peripheral immune evidence; 4.5. Genetic risk factors in PD; 4.6. Epidemiological studies (NSAIDs, steroids); 5. Inflammation in Animal Models of PD; 5.1. Toxin-based models; 5.1.1. 6-Hydroxydopamine; 5.1.2. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 5.1.3. Paraquat; 5.1.4. Rotenone; 5.2. Genetic models; 5.2.1. Evidence of inflammation in transgenic animal models of PD
  • 5.2.2. Relationship between inflammation and PD in inflammation-related gene studies5.3. Inflammatory models; 5.3.1. Lipopolysaccharide; 5.3.2. Polyinosinic:polycytidylic acid; 5.3.3. Prostaglandin J2; 6. Molecular Mechanisms of Inflammation in PD; 6.1. Proinflammatory cytokines; 6.1.1. Tumor necrosis factor; 6.1.2. Interleukin-1; 6.1.3. Interferons; 6.1.4. Fas/Fas ligand; 6.2. Cyclooxygenase-2; 6.3. Oxidative stress; 6.4. Glutamate excitotoxicity; 6.5. Dysfunction of counter-regulatory and immunomodulatory mechanisms; 6.6. Final death pathways; 7. Therapeutic Implications
  • 7.1. Anti-inflammatory drugs
Summary
  • Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all as
  • Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.
  • Review: "The authority, originality, and editing of the reviews are first class." --Nature
Biography
  • Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.
Subject
Other names
Genre
  • Electronic books.
  • text
Language
  • English
Internet Resources
Direct Link
https://copac.jisc.ac.uk/id/27350272?style=html&title=Advances%20in%20Protein%20Chemistry%20and%20Structural%20BiologyInflammation
Format
  • Online

Held At

  1. Manchester University Online Information about Manchester University

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