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Title

Advances in Protein Chemistry : Mechanisms and Pathways of Heterotrimeric G Protein Signaling.

Author
Series
  • (CKB)954926956866
Other titles
  • ADVANCES IN PROTEIN CHEMISTRY, VOLUME 74
  • MECHANISMS AND PATHWAYS OF HETEROTRIMERIC G PROTEIN SIGNALING
  • Advances in Protein Chemistry, Volume 74C
  • Advances in protein chemistry
  • Mechanisms and Pathways of Heterotrimeric G Protein Signaling , Volume 74C
Published
  • Burlington : Elsevier Science 2007
Physical description
1 online resource (262 p.)
ISBN
  • 1281072532
  • 9786611072537
  • 0080552692
  • 012034288X
Notes
  • Description based upon print version of record.
Contents
  • Cover; Contents; Preface; Chapter 1: Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Galpha Proteins; I. Introduction and Scope; II. A Selective Survey of Galpha Protein Structure and Function; III. Mechanisms of Effector Recognition and Regulation by GalphabullGTP; A. A Common Galpha:Effector Interface; B. Functional Consequences of Galpha:Effector Binding; IV. Signal Termination: The Mechanism of GTP Hydrolysis and Conformational Deactivation; A. Structure of the Ground State for GTP Hydrolysis; B. Reaction Trajectory for GTP Hydrolysis
  • V. Signal Termination Through GAPs and Effector GAP DomainsA. Deactivation of Galphaq by PLCbeta; B. RGS GAPs; C. Synergy Between RGS and Effector Domains; D. Deactivation of Galpha 13 by the alphaGAP Element of p115RhoGEF; VI. Conclusions; Acknowledgments; References; Chapter 2: How do Receptors Activate G Proteins?; I. Introduction; A. Structure of Heptahelical Receptors; B. Heterotrimeric G Protein Structure; II. Toward a Model of the Receptor-G Protein Complex; A. Structural Determinants of Receptor-G Protein Specificity; B. Point to Point Interactions Between Receptors and G Proteins
  • C. Current Approaches to Modeling the Receptor-G Protein ComplexIII. Molecular Basis for G Protein Activation; IV. Summary and Conclusions; References; Chapter 3: Some Mechanistic Insights into GPCR Activation from Detergent-Solubilized Ternary Complexes on Beads; I. Perspectives; II. Survey of Experimental Approaches and Representative Data; A. Flow Cytometric Approaches to Assess GPCR Function In Vivo; B. Rapid Mix Flow Cytometry; C. Modular Assembly of Molecular Complexes on Beads; III. Analysis of Soluble Receptor Ternary Complex Assemblies; A. General Considerations
  • B. Simple Ternary Complex Model: General ConsiderationsC. Application of Ternary Complex Model; D. Landscapes of G-Bead Assemblies Based on Application of Experimentally Derived Binding Constants to the Ternary Complex Model; E. Ternary Complex Analysis of Soluble Receptor Assemblies; F. Are Unique Conformational Changes in Receptors Elicited by Interactions with Ligands Resulting in Varied G Protein Interactions by the Ligand-Bound Receptor?; IV. Guanine Nucleotide Activation of Ternary Complex: Some Dynamic Aspects of Structure and Reactivity; A. General Considerations
  • B. Structural StudiesC. Some Dynamic Aspects of GPCR Activation; D. Modular Disassembly of the Ternary Complexes: Guanine Nucleotide Activation Causes the Rapid Separation of the GPCR and Ligand from the G Protein; E. GDP Activity?; F. Galpha Subunit Dissociation?; G. Outlook; Acknowledgments; References; Chapter 4: Activation of G Protein-Coupled Receptors; I. Introduction; II. Structural and Mechanistic Homology Among GPCRs; A. Rhodopsin as a Structural Model for GPCRs; B. GPCRs Activated by Diffusible Agonists; C. GPCR Oligomers; III. Conformational States
  • A. Basal Activity and Ligand Efficacy
Summary
  • This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒÑƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide
  • This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GfNfnfnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.
Subject
Genre
  • Electronic books.
Language
  • English
Internet Resources
Direct Link
https://copac.jisc.ac.uk/id/50848090?style=html&title=Advances%20in%20Protein%20ChemistryMechanisms%20and%20Pathways
Format
  • Online

Held At

  1. Manchester University Online Information about Manchester University

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